Mycobacterium tuberculosis is an obligate human pathogen. However, our understanding of the MTB biology in humans is limited by the difficulty of accessing the sites of infection. Bacterial population genetics provides mechanistic insights into the biology of MTB in people. We have leveraged MTB population genetics to identify genes that are evolving to increase the bacterium’s ability to survive drug pressure. This analysis has revealed a novel regulatory circuit governing the integration of chromosomal replication and cell division. Genetic variation in the circuit components alters cell cycle and the ability to restart growth after antibiotic stress.
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Past PMB Seminars
Transcriptional Governance: Mechanisms of Activation Control for the Auxin Response Factors
The Strader lab has been studying transcriptional output of the Auxin Response Factors, key regulators of plant growth and development, finding that protein condensation, nucleo-cytoplasmic partitioning, and activation domain activity can be modulated to integrate environmental and developmental cues into their transcriptional activity.
Most Delicious Poison: The Story of Nature’s Toxins–from Spices to Vices
I will discuss what motivated me to write a new book on the origin story of toxins made by plants and other organisms that humans use (and sometimes abuse) and I will give an overview of this general audience book.